TAS2R10

Across TCGA patient cohorts, TAS2R10 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R10-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with TAS2R10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R10-to-partner and partner-to-TAS2R10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TAS2R10-low versus TAS2R10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R10→partner) and Y-score (partner→TAS2R10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.209	-2.321	.033	.034	3	1
UCEC	eIF4E →	+0.179	+3.459	.030	.005	3	1
UCEC	ERK2 →	+0.156	+2.321	.039	.034	3	1
UCEC	JNK2 →	+0.239	+3.331	.002	.005	3	1
UCEC	Ku80 →	+0.320	+3.183	<.001	<.001	3	1
UCEC	MEK1_p_S217_S221 →	-0.237	-2.459	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by TAS2R10 expression — UCEC

Explore this box plot interactively →