TAS2R1

Across TCGA pan-cancer cohorts, TAS2R1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TAS2R1 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher TAS2R1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TAS2R1 expression acts as an unfavorable survival marker.

ESCA, HNSC, and OV are the cancer types where TAS2R1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.117	0.703	<.001	36	view →
HNSC	OS	Median	All	0.156	0.710	.002	30	view →
OV	DFS	Median	All	0.276	0.542	.027	18	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TAS2R1–ESCA (OS)

Open the ESCA breakdown →