TAS2R1

Across TCGA patient cohorts, TAS2R1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TAS2R1-associated genes across cancer lineages are p90 RSK_pT359_S363, Raptor, and VHL. Each is linked with TAS2R1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS2R1-to-partner and partner-to-TAS2R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK_pT359_S363 grouped by TAS2R1-low versus TAS2R1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R1→partner) and Y-score (partner→TAS2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p90 RSK_pT359_S363 →	-0.146	-2.459	.045	.020	3	2
LUAD	Raptor →	+0.246	+3.012	.012	.018	2	3
UCEC	VHL →	-1.110	-3.169	.001	.019	3	2
SKCM	ACC1 →	+0.286	+2.222	.028	.010	3	2
SKCM	mTOR →	+0.262	+2.459	.009	.018	3	2
SKCM	Cyclin-B1 →	+0.463	+3.321	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p90 RSK_pT359_S363 by TAS2R1 expression — LUAD

Explore this box plot interactively →