TAS2R1

Across TCGA cell cohorts, TAS2R1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS2R1-associated genes across cancer lineages are CCL16, NEUROD4, and DMRTC2. Each is linked with TAS2R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R1-to-partner and partner-to-TAS2R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL16 grouped by TAS2R1-low versus TAS2R1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R1→partner) and Y-score (partner→TAS2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCL16 →	+0.030	+4.807	<.001	.006	3	1
SOFT_TISSUE	NEUROD4 →	+0.035	+4.417	<.001	.004	3	1
SOFT_TISSUE	DMRTC2 →	+0.019	+4.369	<.001	.008	3	1
SOFT_TISSUE	CLDN8 →	+0.019	+5.515	<.001	<.001	3	1
LUNG_NSCLC_LUAD	CARTPT →	+0.017	+5.266	<.001	.001	3	1
LARGE_INTESTINE	ASPN →	+0.056	+3.378	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

CCL16 by TAS2R1 expression — BLOOD_Myeloma

Explore this box plot interactively →