TAS1R1

Across TCGA pan-cancer cohorts, TAS1R1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TAS1R1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TAS1R1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TAS1R1 expression acts as an unfavorable survival marker.

ACC, THYM, and KICH are the cancer types where TAS1R1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
THYM	OS	Median	All	0.604	0.975	<.001	33	view →
KICH	OS	Median	All	0.161	0.881	<.001	24	view →
HNSC	OS	Median	II,III,IV	0.082	0.711	<.001	24	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
LIHC	OS	Median	All	0.255	0.773	.012	9	view →
LUAD	OS	Median	All	0.313	0.812	.015	9	view →
BLCA	DFS	Median	III,IV	0.200	0.574	.029	6	view →
SKCM	OS	Median	III,IV	0.255	0.840	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TAS1R1–ACC (DFS)

Open the ACC breakdown →