TAS1R1

Across TCGA patient cohorts, TAS1R1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS1R1-associated genes across cancer lineages are ATM, Chk1, and c-Kit. Each is linked with TAS1R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS1R1-to-partner and partner-to-TAS1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TAS1R1-low versus TAS1R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS1R1→partner) and Y-score (partner→TAS1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.542	-2.571	<.001	.010	3	2
UCEC	Chk1 →	-0.125	-2.222	.032	.009	3	2
SKCM	c-Kit →	-0.661	-2.700	.024	.006	3	2
UCEC	EGFR_pY1068 →	-0.250	-2.000	.004	.003	3	1
UCEC	EGFR →	-0.135	-2.459	.016	.019	3	1
UCEC	A-Raf_pS299 →	-0.123	-2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by TAS1R1 expression — UCEC

Explore this box plot interactively →