TAS1R1

Across TCGA cell cohorts, TAS1R1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS1R1-associated genes across cancer lineages are TCP11X1, GAGE13, and GALP. Each is linked with TAS1R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS1R1-to-partner and partner-to-TAS1R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X1 grouped by TAS1R1-low versus TAS1R1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS1R1→partner) and Y-score (partner→TAS1R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TCP11X1 →	+0.004	+4.662	<.001	.003	3	2
BLOOD_Lymphoma	GAGE13 →	+0.953	+4.192	.005	.003	3	2
LARGE_INTESTINE	GALP →	+0.011	+3.700	<.001	.009	3	2
LARGE_INTESTINE	CCER1 →	+0.009	+3.562	<.001	.002	3	2
LUNG_NSCLC_LUAD	USP29 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	EZHIP →	+0.170	+3.874	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TCP11X1 by TAS1R1 expression — BLOOD_Lymphoma

Explore this box plot interactively →