Across TCGA patient cohorts, TARS3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TARS3-associated genes across cancer lineages are MEK1, p27, and MSH2. Each is linked with TARS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TARS3-to-partner and partner-to-TARS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS3→partner) and Y-score (partner→TARS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEK1 →	+0.464	+3.169	.016	.019	3	3
SKCM	p27 →	+0.256	+2.824	.009	.034	3	2
UCEC	MSH2 →	-0.277	-3.312	.009	.010	3	1
UCEC	MSH6 →	-0.316	-2.999	.040	.035	3	1
UCEC	Notch1 →	+0.241	+2.584	<.001	.011	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.471	-3.000	.024	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

TARS3 survival (RNA) · tumor vs normal (RNA) · all TARS3 data types