Across TCGA cell cohorts, TARS3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TARS3-associated genes across cancer lineages are LORICRIN, GSG1L2, and OR12D3. Each is linked with TARS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARS3-to-partner and partner-to-TARS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS3→partner) and Y-score (partner→TARS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LORICRIN →	+0.528	+4.339	<.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
OVARY	OR12D3 →	+0.016	+5.807	<.001	.001	3	1
OVARY	DEFA6 →	+0.111	+5.196	.004	.005	3	1
BREAST	OR10K2 →	+0.038	+4.196	<.001	.006	3	1
BREAST	OR10T2 →	+0.110	+4.196	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

TARS3 survival (RNA) · tumor vs normal (RNA) · all TARS3 data types