TARS2

Across TCGA patient cohorts, TARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,818 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TARS2-associated genes across cancer lineages are FEZ1, PRUNE1, and EHD4. Each is linked with TARS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TARS2-to-partner and partner-to-TARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TARS2 versus FEZ1 in HNSC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS2→partner) and Y-score (partner→TARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FEZ1 →	-0.789	-0.301	<.001	<.001	3	6
LSCC	PRUNE1 →	+0.532	+0.449	<.001	<.001	3	6
CCRCC	EHD4 →	-0.528	-0.310	<.001	<.001	3	5
OV	FBXW7 →	-0.625	-0.548	<.001	<.001	3	5
BRCA	GNAI2 →	-0.428	-0.309	.002	.003	3	5
OV	PDE1A →	-0.950	-0.500	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,818 associations by consensus.

TARS2 vs FEZ1 — HNSC

Explore this scatter interactively →