TARS2

Across TCGA patient cohorts, TARS2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TARS2-associated genes across cancer lineages are Caspase-7-cleavedD198, Akt_pT308, and PAI-1. Each is linked with TARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TARS2-to-partner and partner-to-TARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TARS2-low versus TARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS2→partner) and Y-score (partner→TARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.945	+3.169	<.001	.018	3	3
COAD	Akt_pT308 →	+0.411	+2.815	.020	.036	3	1
COAD	PAI-1 →	+1.002	+2.815	.002	.036	3	1
COAD	TAZ →	+0.310	+2.832	.004	.035	3	1
UCEC	EGFR_pY1068 →	-0.286	-2.584	.007	.010	3	1
UCEC	eIF4E →	+0.213	+3.013	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by TARS2 expression — UCEC

Explore this box plot interactively →