TARS2

Across TCGA cell cohorts, TARS2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TARS2-associated genes across cancer lineages are SH3GL2, IL17A, and DCD. Each is linked with TARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARS2-to-partner and partner-to-TARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by TARS2-low versus TARS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS2→partner) and Y-score (partner→TARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.326	+3.474	<.001	.003	3	1
BLOOD_Leukemia	IL17A →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	DCD →	+0.025	+4.384	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
CNS	CHRNB3 →	+0.031	+4.584	.004	.001	3	1
CNS	HTR4 →	+0.039	+3.874	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SH3GL2 by TARS2 expression — LARGE_INTESTINE

Explore this box plot interactively →