TARS1

Across TCGA patient cohorts, TARS1 mutation is significantly associated with the RNA expression of many other genes, with 2,649 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TARS1-associated genes across cancer lineages are LIPF, SLC6A12-AS1, and TUBAP4. Each is linked with TARS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TARS1-to-partner and partner-to-TARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIPF grouped by TARS1-low versus TARS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS1→partner) and Y-score (partner→TARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LIPF →	+1.075	+3.259	<.001	.005	3	3
BRCA	SLC6A12-AS1 →	+0.219	+3.716	.004	.007	3	2
HNSC	TUBAP4 →	+0.102	+4.245	.007	.008	3	2
COAD	SLCO1B3-SLCO1B7 →	+0.123	+3.750	.008	.004	3	2
SKCM	LINC00313 →	+0.112	+2.854	<.001	.009	3	2
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,649 associations by consensus.

LIPF by TARS1 expression — COAD

Explore this box plot interactively →