TARDBP

Across TCGA patient cohorts, TARDBP mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TARDBP-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with TARDBP in more than 3 cancer types. Because this analysis shows association rather than direction, both TARDBP-to-partner and partner-to-TARDBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TARDBP-low versus TARDBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARDBP→partner) and Y-score (partner→TARDBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.418	-1.584	.010	.019	3	4
UCEC	EGFR_pY1068 →	-0.237	-2.222	.008	.010	3	2
UCEC	eIF4E →	+0.205	+2.321	.007	.001	3	2
UCEC	Rad50 →	-0.233	-2.321	.007	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.500	+1.894	.019	.030	3	2
UCEC	14-3-3_beta →	-0.122	-3.780	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by TARDBP expression — UCEC

Explore this box plot interactively →