TARBP2

Across TCGA patient cohorts, TARBP2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TARBP2-associated genes across cancer lineages are A-Raf_pS299, mTOR_pS2448, and PRAS40_pT246. Each is linked with TARBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARBP2-to-partner and partner-to-TARBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TARBP2-low versus TARBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARBP2→partner) and Y-score (partner→TARBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.223	-3.459	<.001	.005	3	2
UCEC	mTOR_pS2448 →	-0.160	-3.150	.017	.019	3	2
UCEC	PRAS40_pT246 →	+0.162	+3.169	.036	.019	3	2
UCEC	Rictor_pT1135 →	-0.116	-3.321	.012	.010	3	2
UCEC	ASNS →	+0.471	+3.321	.003	.010	3	2
UCEC	C-Raf →	+0.232	+3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

A-Raf_pS299 by TARBP2 expression — UCEC

Explore this box plot interactively →