TARBP1

Across TCGA patient cohorts, TARBP1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TARBP1-associated genes across cancer lineages are ERK2, eIF4E, and GATA6. Each is linked with TARBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARBP1-to-partner and partner-to-TARBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TARBP1-low versus TARBP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARBP1→partner) and Y-score (partner→TARBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.203	+2.459	.044	.020	3	2
UCEC	eIF4E →	+0.189	+2.820	.003	.001	3	2
UCEC	GATA6 →	-0.146	-2.792	.003	.002	3	2
UCEC	INPP4B →	-0.265	-2.169	.008	.002	3	2
UCEC	MEK1 →	+0.344	+1.999	.002	.002	3	2
UCEC	p62 Lck ligand →	+0.378	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ERK2 by TARBP1 expression — SKCM

Explore this box plot interactively →