TARBP1

Across TCGA cell cohorts, TARBP1 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TARBP1-associated genes across cancer lineages are APOL5, KHDRBS2, and TRIM60. Each is linked with TARBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARBP1-to-partner and partner-to-TARBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by TARBP1-low versus TARBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARBP1→partner) and Y-score (partner→TARBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	2
OESOPHAGUS	KHDRBS2 →	+0.603	+4.906	<.001	.006	3	1
CNS	TRIM60 →	+0.003	+4.357	<.001	.004	3	1
LARGE_INTESTINE	HMGXB4 →	+0.706	+3.067	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.510	+3.474	<.001	.003	3	1
LARGE_INTESTINE	NFE2L2 →	+0.863	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

APOL5 by TARBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →