TARBP1

Across TCGA cell cohorts, TARBP1 mutation is significantly associated with the mutation status of many other genes, with 5,928 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TARBP1-associated genes across cancer lineages are FREM1, ZSWIM8, and POLQ. Each is linked with TARBP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TARBP1-to-partner and partner-to-TARBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FREM1 grouped by TARBP1-low versus TARBP1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARBP1→partner) and Y-score (partner→TARBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FREM1 →	+5.000	+5.000	.006	.006	1	5
BLOOD_Leukemia	ZSWIM8 →	+2.690	+2.762	.005	.005	1	5
BREAST	POLQ →	+3.442	+4.558	.003	.003	1	4
BREAST	CACNA1I →	+3.121	+4.339	.005	.005	1	4
BREAST	ITGA4 →	+4.857	+4.297	.009	.009	1	4
BREAST	ITPR2 →	+3.857	+4.807	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,928 associations by consensus.

FREM1 by TARBP1 expression — KIDNEY

Explore this box plot interactively →