TAPT1

Across TCGA patient cohorts, TAPT1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAPT1-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and 14-3-3_beta. Each is linked with TAPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAPT1-to-partner and partner-to-TAPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TAPT1-low versus TAPT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAPT1→partner) and Y-score (partner→TAPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.197	-1.874	.023	.049	3	2
UCEC	PDCD4 →	-0.504	-2.459	.001	.018	3	2
UCEC	14-3-3_beta →	-0.081	-1.780	.019	.024	3	1
UCEC	eIF4E →	+0.147	+2.472	.043	.010	3	1
UCEC	eIF4G →	+0.269	+2.459	.012	.018	3	1
UCEC	A-Raf_pS299 →	-0.129	-2.070	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by TAPT1 expression — UCEC

Explore this box plot interactively →