TAPBPL

Across TCGA patient cohorts, TAPBPL mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAPBPL-associated genes across cancer lineages are INPP4B, JNK2, and Mre11. Each is linked with TAPBPL in more than 1 cancer types. Because this analysis shows association rather than direction, both TAPBPL-to-partner and partner-to-TAPBPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TAPBPL-low versus TAPBPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAPBPL→partner) and Y-score (partner→TAPBPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.404	-3.321	.009	.010	3	1
UCEC	JNK2 →	+0.190	+3.009	.048	.019	3	1
UCEC	Mre11 →	-0.099	-2.973	.016	.035	3	1
UCEC	S6_pS240_S244 →	+0.738	+3.584	<.001	.002	3	1
UCEC	Tuberin_pT1462 →	+0.292	+2.179	.008	.034	3	1
UCEC	Tuberin →	+0.350	+2.459	.007	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

INPP4B by TAPBPL expression — UCEC

Explore this box plot interactively →