TAPBP

Across TCGA pan-cancer cohorts, TAPBP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TAPBP data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TAPBP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TAPBP expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

COAD, LUAD, and LSCC are the cancer types where TAPBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.860	1.000	.007	102	view →
LUAD	DFS	Median	III,IV	0.778	0.267	<.001	24	view →
LSCC	OS	Tertile	II,III,IV	0.518	0.938	.003	9	view →
HNSC	OS	Quartile	IV	0.794	0.462	.035	6	view →
PDAC	OS	Quartile	II,III,IV	0.995	0.818	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TAPBP–COAD (DFS)

Open the COAD breakdown →