TAPBP

Across TCGA patient cohorts, TAPBP mutation is significantly associated with the RNA expression of many other genes, with 2,069 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAPBP-associated genes across cancer lineages are RNU6-591P, FAM138D, and RNA5SP54. Each is linked with TAPBP in more than 2 cancer types. Because this analysis shows association rather than direction, both TAPBP-to-partner and partner-to-TAPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-591P grouped by TAPBP-low versus TAPBP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAPBP→partner) and Y-score (partner→TAPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-591P →	+0.192	+4.618	<.001	.005	3	3
BLCA	FAM138D →	+0.025	+4.618	<.001	.005	3	2
BLCA	RNA5SP54 →	+0.246	+5.040	<.001	.002	3	2
UCEC	RNA5SP443 →	+0.249	+2.357	<.001	<.001	3	2
UCEC	AKR1B1P3 →	+0.175	+1.955	.009	.004	3	2
UCEC	RNA5SP413 →	+1.198	+2.036	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,069 associations by consensus.

RNU6-591P by TAPBP expression — BLCA

Explore this box plot interactively →