TAPBP

Across TCGA patient cohorts, TAPBP mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAPBP-associated genes across cancer lineages are Notch1, Annexin-1, and EGFR_pY1068. Each is linked with TAPBP in more than 1 cancer types. Because this analysis shows association rather than direction, both TAPBP-to-partner and partner-to-TAPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TAPBP-low versus TAPBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAPBP→partner) and Y-score (partner→TAPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.143	+2.335	.014	.018	3	2
UCEC	Annexin-1 →	+0.466	+2.189	.032	.034	3	2
UCEC	EGFR_pY1068 →	-0.241	-1.807	.020	.027	3	1
UCEC	Heregulin →	-0.116	-2.700	.022	.006	3	1
UCEC	INPP4B →	-0.370	-2.700	.005	.006	3	1
UCEC	Ku80 →	+0.252	+3.013	.009	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Notch1 by TAPBP expression — UCEC

Explore this box plot interactively →