Across TCGA patient cohorts, TAP2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAP2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and Ku80. Each is linked with TAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAP2-to-partner and partner-to-TAP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAP2→partner) and Y-score (partner→TAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.778	+3.019	.006	.019	3	2
UCEC	14-3-3_beta →	-0.103	-2.973	.033	.035	3	1
UCEC	Ku80 →	+0.392	+3.598	<.001	.001	3	1
UCEC	Notch1 →	+0.180	+2.820	.008	.035	3	1
UCEC	p27_pT198 →	+0.106	+3.169	.041	.019	3	1
UCEC	c-Met_pY1235 →	+0.095	+2.331	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

TAP2 survival (RNA) · tumor vs normal (RNA) · all TAP2 data types