Across TCGA cell cohorts, TAP2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TAP2-associated genes across cancer lineages are REG1B, HSFY2, and ADGRA1. Each is linked with TAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAP2-to-partner and partner-to-TAP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAP2→partner) and Y-score (partner→TAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	REG1B →	+0.034	+4.734	<.001	.002	3	3
LUNG_NSCLC_LUAD	HSFY2 →	+0.033	+4.371	<.001	.005	3	2
SKIN	ADGRA1 →	+0.004	+2.925	<.001	.007	3	2
LUNG_NSCLC_LUSC	ETDC →	+0.593	+4.643	<.001	.008	3	1
CNS	TAAR9 →	+0.025	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR5AR1 →	+0.040	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

TAP2 survival (RNA) · tumor vs normal (RNA) · all TAP2 data types