TAP1

Across TCGA patient cohorts, TAP1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAP1-associated genes across cancer lineages are ATM, PCNA, and IGFBP2. Each is linked with TAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAP1-to-partner and partner-to-TAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TAP1-low versus TAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAP1→partner) and Y-score (partner→TAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.563	-2.247	<.001	.001	3	3
UCEC	PCNA →	+0.196	+1.847	.013	.008	3	2
UCEC	IGFBP2 →	-0.627	-2.459	.008	.018	3	1
UCEC	INPP4B →	-0.251	-2.700	.034	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.151	-1.489	.014	.030	3	1
UCEC	JNK2 →	+0.228	+2.247	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by TAP1 expression — UCEC

Explore this box plot interactively →