TAP1

Across TCGA cell cohorts, TAP1 mutation is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAP1-associated genes across cancer lineages are KRTAP9-8, GCAT, and RPL3. Each is linked with TAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAP1-to-partner and partner-to-TAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-8 grouped by TAP1-low versus TAP1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAP1→partner) and Y-score (partner→TAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KRTAP9-8 →	+0.036	+5.285	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.607	+3.364	<.001	.002	3	1
LARGE_INTESTINE	RPL3 →	+0.499	+3.067	.004	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.893	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PLEKHJ1 →	+0.570	+3.364	.002	.002	3	1
LARGE_INTESTINE	TWNK →	+0.430	+3.364	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

KRTAP9-8 by TAP1 expression — STOMACH

Explore this box plot interactively →