TAOK3

Across TCGA patient cohorts, TAOK3 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAOK3-associated genes across cancer lineages are PDCD4, A-Raf_pS299, and p38-MAPK_pT180_Y182. Each is linked with TAOK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TAOK3-to-partner and partner-to-TAOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TAOK3-low versus TAOK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAOK3→partner) and Y-score (partner→TAOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.576	-1.716	<.001	.003	3	3
STAD	A-Raf_pS299 →	-0.151	-3.000	.006	.034	3	2
STAD	p38-MAPK_pT180_Y182 →	-0.669	-3.000	<.001	.036	3	2
COAD	ATM →	-0.519	-2.313	.003	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.066	+2.330	.002	.020	1	4
UCEC	EGFR_pY1068 →	-0.290	-2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

PDCD4 by TAOK3 expression — UCEC

Explore this box plot interactively →