TAOK1

Across TCGA patient cohorts, TAOK1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAOK1-associated genes across cancer lineages are ATM, 4E-BP1, and eIF4E. Each is linked with TAOK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAOK1-to-partner and partner-to-TAOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TAOK1-low versus TAOK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAOK1→partner) and Y-score (partner→TAOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.512	-2.000	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.234	+2.584	.007	.010	3	3
UCEC	eIF4E →	+0.177	+2.000	.009	<.001	3	2
UCEC	GAPDH →	+0.448	+2.115	.010	.016	3	2
UCEC	PCNA →	+0.211	+2.807	.002	.002	3	2
UCEC	PDCD4 →	-0.486	-2.807	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by TAOK1 expression — UCEC

Explore this box plot interactively →