TANGO6

Across TCGA pan-cancer cohorts, TANGO6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TANGO6 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TANGO6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TANGO6 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and COAD are the cancer types where TANGO6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.387	0.943	.008	18	view →
CCRCC	DFS	Median	II,III,IV	0.474	0.746	.021	10	view →
COAD	DFS	Median	III,IV	0.784	1.000	.038	6	view →
HNSC	DFS	Tertile	III,IV	0.676	0.899	.009	4	view →
PDAC	OS	Quartile	III,IV	0.293	0.631	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TANGO6–LSCC (OS)

Open the LSCC breakdown →