TANGO6

Across TCGA patient cohorts, TANGO6 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TANGO6-associated genes across cancer lineages are MEK1, p27_pT198, and PCNA. Each is linked with TANGO6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TANGO6-to-partner and partner-to-TANGO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TANGO6-low versus TANGO6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TANGO6→partner) and Y-score (partner→TANGO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.351	+2.807	.006	.003	3	2
UCEC	p27_pT198 →	+0.108	+2.000	.004	.030	3	2
COAD	PCNA →	+0.281	+3.008	.029	.019	3	2
UCEC	Shc_pY317 →	-0.154	-2.000	.004	.003	3	2
UCEC	4E-BP1_pT37_T46 →	-0.318	-1.986	.016	.029	3	2
COAD	ASNS →	+0.926	+3.008	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MEK1 by TANGO6 expression — UCEC

Explore this box plot interactively →