TANC2

Across TCGA pan-cancer cohorts, TANC2 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TANC2 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TANC2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TANC2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, UCEC, and KIRC are the cancer types where TANC2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →
UCEC	DFS	Median	All	0.892	0.620	.018	16	view →
KIRC	OS	Median	All	0.127	0.874	<.001	12	view →
KIRP	DFS	Median	II,III,IV	0.038	0.783	<.001	12	view →
LAML	DFS	Median	All	0.081	0.572	.003	12	view →
LUAD	OS	Median	All	0.346	0.702	.003	12	view →
PCPG	DFS	Median	All	0.094	0.768	.008	6	view →
LGG	DFS	Median	All	0.249	0.728	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TANC2–SCLC (DFS)

Open the SCLC breakdown →