TANC2

Across TCGA pan-cancer cohorts, TANC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TANC2 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TANC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TANC2 expression acts as an unfavorable survival marker, although some lineages such as OV and GBM show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where TANC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.298	0.541	<.001	65	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	24	view →
LSCC	DFS	Quartile	II,III,IV	0.683	0.926	.028	5	view →
OV	DFS	Median	All	1.000	0.870	.046	4	view →
LUAD	DFS	Median	All	0.468	0.747	.010	3	view →
GBM	DFS	Quartile	All	0.941	0.684	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TANC2–PDAC (DFS)

Open the PDAC breakdown →