TANC2

Across TCGA pan-cancer cohorts, TANC2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TANC2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TANC2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TANC2 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where TANC2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TANC2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.590	<.001	12	view →
CCRCC	All	II,III,IV	+0.306	<.001	11	view →
LUAD	Female	All	+0.462	<.001	8	view →
LSCC	Male	II,III,IV	−0.163	.001	4	view →
PDAC	Male	All	+0.329	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TANC2–HNSC

Open the HNSC breakdown →