TANC1

Across TCGA patient cohorts, TANC1 mutation is significantly associated with the RNA expression of many other genes, with 6,456 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TANC1-associated genes across cancer lineages are FBXO22, PARP3, and SEH1L. Each is linked with TANC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TANC1-to-partner and partner-to-TANC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO22 grouped by TANC1-low versus TANC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TANC1→partner) and Y-score (partner→TANC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO22 →	+0.438	+1.995	<.001	<.001	3	5
COAD	PARP3 →	+0.464	+2.509	.002	.009	3	5
STAD	SEH1L →	+0.642	+3.824	<.001	<.001	3	5
STAD	ALKBH2 →	+0.555	+3.471	.001	.002	3	4
STAD	BLOC1S2 →	+0.482	+2.733	<.001	.003	3	4
STAD	MTA2 →	+0.529	+2.700	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,456 associations by consensus.

FBXO22 by TANC1 expression — UCEC

Explore this box plot interactively →