TAMALIN

Across TCGA patient cohorts, TAMALIN mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAMALIN-associated genes across cancer lineages are ACC1, p62 Lck ligand, and Annexin-1. Each is linked with TAMALIN in more than 1 cancer types. Because this analysis shows association rather than direction, both TAMALIN-to-partner and partner-to-TAMALIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by TAMALIN-low versus TAMALIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAMALIN→partner) and Y-score (partner→TAMALIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.598	+3.169	.002	.020	3	1
UCEC	p62 Lck ligand →	+0.434	+3.009	.015	.019	3	1
UCEC	Annexin-1 →	+0.850	+3.019	.003	.019	3	1
UCEC	FoxM1 →	+0.307	+3.169	.030	.020	1	1
UCEC	Notch1 →	+0.267	+3.169	<.001	.020	1	1
UCEC	BRD4 →	+0.446	+3.177	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ACC1 by TAMALIN expression — UCEC

Explore this box plot interactively →