TAL1

Across TCGA patient cohorts, TAL1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAL1-associated genes across cancer lineages are EGFR_pY1068, Ku80, and p62 Lck ligand. Each is linked with TAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAL1-to-partner and partner-to-TAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TAL1-low versus TAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAL1→partner) and Y-score (partner→TAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.245	-2.000	.030	.032	3	1
UCEC	Ku80 →	+0.312	+2.013	.003	.018	3	1
UCEC	p62 Lck ligand →	+0.335	+2.469	.022	.010	3	1
UCEC	Annexin-1 →	+0.599	+2.189	.011	.034	3	1
UCEC	Tuberin_pT1462 →	+0.262	+2.000	.011	.032	3	1
UCEC	Tuberin →	+0.408	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by TAL1 expression — UCEC

Explore this box plot interactively →