TAL1

Across TCGA cell cohorts, TAL1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TAL1-associated genes across cancer lineages are ACER1, MYF5, and URAD. Each is linked with TAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAL1-to-partner and partner-to-TAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by TAL1-low versus TAL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAL1→partner) and Y-score (partner→TAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACER1 →	+0.028	+4.977	<.001	.007	3	1
LUNG_SCLC	MYF5 →	+0.060	+5.643	<.001	.002	3	1
LUNG_SCLC	URAD →	+0.044	+5.029	<.001	.006	3	1
LUNG_SCLC	GDF3 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	MUC22 →	+0.016	+5.029	<.001	.006	3	1
BLOOD_Leukemia	REG3G →	+0.065	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ACER1 by TAL1 expression — SKIN

Explore this box plot interactively →