TAGLN2

Across TCGA pan-cancer cohorts, TAGLN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TAGLN2 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TAGLN2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TAGLN2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where TAGLN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.646	0.945	<.001	60	view →
CCRCC	OS	Median	III,IV	0.202	0.985	.007	22	view →
GBM	DFS	Median	All	0.649	0.829	.009	12	view →
LUAD	DFS	Median	All	0.837	0.959	.008	9	view →
HNSC	OS	Quartile	All	0.704	0.934	.010	6	view →
UCEC	DFS	Quartile	All	0.962	0.786	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TAGLN2–LSCC (OS)

Open the LSCC breakdown →