TAGAP

Across TCGA patient cohorts, TAGAP mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAGAP-associated genes across cancer lineages are JNK2, Snail, and Notch1. Each is linked with TAGAP in more than 1 cancer types. Because this analysis shows association rather than direction, both TAGAP-to-partner and partner-to-TAGAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TAGAP-low versus TAGAP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAGAP→partner) and Y-score (partner→TAGAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JNK2 →	+0.252	+3.000	.013	.034	3	2
SKCM	Snail →	-0.170	-3.157	.047	.018	3	2
UCEC	Notch1 →	+0.165	+1.594	<.001	.021	3	2
UCEC	Paxillin →	+0.196	+1.495	.028	.034	3	2
UCEC	Src_pY416 →	-0.215	-1.906	.010	.015	3	2
UCEC	ATM →	-0.485	-4.000	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

JNK2 by TAGAP expression — SKCM

Explore this box plot interactively →