Across TCGA pan-cancer cohorts, TAFA5 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TAFA5 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.
The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TAFA5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TAFA5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.
STAD, HNSC, and COAD are the cancer types where TAFA5 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.