TAFA4

Across TCGA patient cohorts, TAFA4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAFA4-associated genes across cancer lineages are STAT3_pY705, eEF2, and EGFR_pY1068. Each is linked with TAFA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAFA4-to-partner and partner-to-TAFA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TAFA4-low versus TAFA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAFA4→partner) and Y-score (partner→TAFA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.498	-2.906	<.001	.001	3	2
UCEC	eEF2 →	+0.312	+1.700	.040	.044	3	1
UCEC	EGFR_pY1068 →	-0.276	-1.700	.009	.044	3	1
UCEC	eIF4E →	+0.191	+2.222	.033	.011	3	1
UCEC	FASN →	+0.394	+2.222	.018	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.163	-3.000	.023	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

STAT3_pY705 by TAFA4 expression — UCEC

Explore this box plot interactively →