TAF6L

Across TCGA pan-cancer cohorts, TAF6L RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TAF6L data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TAF6L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TAF6L expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

ACC, SCLC, and HNSC are the cancer types where TAF6L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.445	0.796	<.001	92	view →
SCLC	OS	Median	II,III,IV	1.000	0.421	.002	48	view →
HNSC	OS	Quartile	All	0.899	0.734	<.001	40	view →
LGG	DFS	Median	All	0.784	0.877	<.001	33	view →
STAD	DFS	Median	II,III,IV	0.797	0.566	.002	31	view →
KICH	OS	Tertile	II,III,IV	0.717	1.000	.013	25	view →
MESO	DFS	Tertile	IV	0.224	0.587	.003	24	view →
READ	OS	Tertile	All	1.000	0.527	.010	23	view →
COAD	DFS	Tertile	IV	0.289	0.891	.002	18	view →
LUSC	DFS	Tertile	III,IV	0.417	1.000	.007	16	view →
LIHC	DFS	Tertile	All	0.326	0.490	.002	15	view →
OV	OS	Tertile	IV	0.519	0.240	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TAF6L–ACC (OS)

Open the ACC breakdown →