TAF6

Across TCGA patient cohorts, TAF6 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF6-associated genes across cancer lineages are p27_pT157, MEK1, and p53. Each is linked with TAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF6-to-partner and partner-to-TAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by TAF6-low versus TAF6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF6→partner) and Y-score (partner→TAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p27_pT157 →	+0.130	+2.834	.007	.035	3	2
UCEC	MEK1 →	+0.284	+2.169	.016	.003	3	2
UCEC	p53 →	-0.263	-2.000	.036	.029	3	2
UCEC	PARP_cleaved →	-0.201	-2.115	.044	.016	3	2
UCEC	Annexin-1 →	+0.549	+2.222	.001	.009	3	2
UCEC	Shc_pY317 →	-0.139	-2.000	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p27_pT157 by TAF6 expression — LUSC

Explore this box plot interactively →