TAF5L

Across TCGA pan-cancer cohorts, TAF5L mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TAF5L’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TAF5L mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TAF5L is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where TAF5L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAF5L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.203	.027	4	view →
LSCC	Male	All	+0.113	<.001	4	view →
LUAD	All	All	+0.090	<.001	4	view →
COAD	All	IV	+1.070	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TAF5L–PDAC

Open the PDAC breakdown →