TAF5L

Across TCGA patient cohorts, TAF5L mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF5L-associated genes across cancer lineages are Shc_pY317, ATM, and 14-3-3_beta. Each is linked with TAF5L in more than 2 cancer types. Because this analysis shows association rather than direction, both TAF5L-to-partner and partner-to-TAF5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TAF5L-low versus TAF5L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF5L→partner) and Y-score (partner→TAF5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.137	-1.925	.012	.005	3	3
UCEC	ATM →	-0.628	-2.794	<.001	.002	3	3
UCEC	14-3-3_beta →	-0.121	-3.880	<.001	<.001	3	2
UCEC	N-Ras →	-0.101	-2.295	.018	.033	3	2
UCEC	Akt_pS473 →	+0.770	+1.584	.002	.034	3	2
UCEC	Rad50 →	-0.245	-1.584	.005	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Shc_pY317 by TAF5L expression — UCEC

Explore this box plot interactively →