TAF5L

Across TCGA cell cohorts, TAF5L mutation is significantly associated with the mutation status of many other genes, with 3,677 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAF5L-associated genes across cancer lineages are DOCK4, PLCB1, and CDC42BPB. Each is linked with TAF5L in more than 6 cancer types. Because this analysis shows association rather than direction, both TAF5L-to-partner and partner-to-TAF5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOCK4 grouped by TAF5L-low versus TAF5L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF5L→partner) and Y-score (partner→TAF5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DOCK4 →	+3.055	+3.786	.006	.006	1	7
BLOOD_Lymphoma	PLCB1 →	+2.969	+3.337	.009	.009	1	5
BREAST	CDC42BPB →	+4.297	+4.857	.009	.009	1	5
BLOOD_Lymphoma	UBE3A →	+4.969	+4.014	.008	.008	1	5
CNS	SLC4A3 →	+5.277	+4.459	.005	.005	1	5
LARGE_INTESTINE	ADAMTS18 →	+1.757	+2.278	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,677 associations by consensus.

DOCK4 by TAF5L expression — CNS

Explore this box plot interactively →