TAF4B

Across TCGA patient cohorts, TAF4B mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF4B-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and A-Raf_pS299. Each is linked with TAF4B in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF4B-to-partner and partner-to-TAF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by TAF4B-low versus TAF4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF4B→partner) and Y-score (partner→TAF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.072	+1.710	.008	.025	3	2
UCEC	EGFR_pY1068 →	-0.246	-1.847	.007	.008	3	1
UCEC	A-Raf_pS299 →	-0.106	-3.459	.016	.005	3	1
UCEC	ERK2 →	+0.152	+1.502	.032	.030	3	1
UCEC	JNK2 →	+0.275	+2.232	<.001	.005	3	1
UCEC	Ku80 →	+0.230	+1.861	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

c-Met_pY1235 by TAF4B expression — UCEC

Explore this box plot interactively →