TAF4

Across TCGA patient cohorts, TAF4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF4-associated genes across cancer lineages are eIF4E, p21, and PCNA. Each is linked with TAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF4-to-partner and partner-to-TAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TAF4-low versus TAF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF4→partner) and Y-score (partner→TAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.169	+2.598	.013	.005	3	2
UCEC	p21 →	+0.144	+2.321	.021	.005	3	2
UCEC	PCNA →	+0.266	+2.700	<.001	<.001	3	2
UCEC	PDCD4 →	-0.569	-2.906	<.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.072	-1.459	.030	.012	3	2
UCEC	Src_pY416 →	-0.182	-1.502	.019	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by TAF4 expression — UCEC

Explore this box plot interactively →