TAF3

Across TCGA pan-cancer cohorts, TAF3 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TAF3 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TAF3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TAF3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

BRCA, LUAD, and HNSC are the cancer types where TAF3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.113	0.579	<.001	24	view →
LUAD	OS	Median	All	0.289	0.679	.006	24	view →
HNSC	DFS	Median	All	0.149	0.604	.004	24	view →
OV	OS	Median	II,III,IV	0.422	0.692	.035	18	view →
UCEC	OS	Median	III,IV	0.925	0.542	.024	10	view →
LIHC	DFS	Median	All	0.085	0.555	.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	OS	Median	All	0.137	0.545	.033	3	view →
SKCM	DFS	Median	II,III,IV	0.779	0.544	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TAF3–BRCA (OS)

Open the BRCA breakdown →